Regulation Of Irk Activity Summary

The foregoing has identified a number of factors involved in the regulation of IRK activity. Those recognized to date are summarized in Table 4 where it can be seen that four out of the six known mechanisms are processes that occur in the endosomal system. This highlights the significance of the endosomal system in mediating and regulating the insulin response. As alluded to previously it is possible that disturbances in endosomal regulatory processes might contribute to the pathogenesis of NIDDM.

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