The Need for Terminating Tcell Activity

It is reasonable to think that survival of the host relies on the activation of an effective immune response; however, some immune responses can also jeopardize host survival. The need to terminate a T-cell response is necessary to maintain homeostasis. Here T-cell responses are terminated to prevent activation when there is no noxious pathogen, or when a noxious pathogen has been cleared. Termination of T-cell responses is necessary when there is a hyper-sensitivity response that permanently damages tissues and organs such as in the eye. There is also the desire to therapeutically terminate T-cell activity to treat autoimmune disease and transplant graft rejection. The mechanisms of terminating Th-cell activity are the means by which the adaptive immune response establishes homeostasis, self-tolerance, and immune privilege.

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