In conclusion, exposure to chronic hypoxia is associated with the activation of endogenous lung angiogenic processes, which attenuate the severity of pulmonary hypertension. Recent studies also provide evidence that the angiopoietin-1/Tie2 pathway is abnormal in idiopathic PAH and contributes to PA-SMC hyperplasia through excessive release of growth factors by ECs. Since Ang1 is now considered a pericyte-derived paracrine signal for the endothelium, these findings identify dysregulation of cross-talk between endothelial and smooth muscle cells as an important component of pulmonary vascular remodeling. Further studies are needed to better understand the importance of these abnormalities in the process of hypoxia-induced smooth muscle proliferation.

Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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