Hemodynamic Studies

Only a few hemodynamic studies of PHAHD or ISMS have been performed at high altitude during hospital admission. Cardiac catheterizations were performed in 15 patients. One in La Oroya (3730 m), Peru, and a repeat catheterization was performed at sea level [12]; seven cases were done in Leadville (3100 m), CO [8,17]; and eight patients developed PHAHD at altitudes between 3008m and 4280 m, while catheterizations were performed in Xining (2261 m), Qinghai, and compared with the results of 12 normal infants living at 2261 m [44]. The results are summarized in Table 2.

Pulmonary hypertension was presented in all, the mean pulmonary artery pressure (MPAP) ranging from 33±2 mmHg to 47±24 mmHg, with a normal pulmonary wedge pressure (4-8 mmHg). Pulmonary vascular resistances were increased to 686-1078 dynes/sec/cm. The administration of 100 percent oxygen rapidly lower PAP but normal values were not reached. Exercise and induced hypoxia resulted in a marked rise in pressure.

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