Oxidative Stress in Pulmonary Hypertension

The association of oxidative stress with pulmonary hypertension is increasingly recognised. Markers of oxidative stress are increased in patients with pulmonary hypertension [6,16,59]. Superoxide mediates pulmonary smooth muscle cell proliferation after exposure to endothe-lin-1 [85], and pulmonary vasoconstriction after exposure to 5-HT [49]. Increased superoxide production from NADPH oxidase has been associated with pulmonary hypertension in foetal lambs after in-utero ductal ligation [8]. Superoxide produced from xanthine oxidase appears to contribute to the development of hypoxia-induced pulmonary hypertension in rodents [35].

Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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