There was a statistically significant difference among the three groups in changes from baseline to week 12 in mean PAP measured 8-10 hours postdose (trough) (p=0.039). Sildenafil 25 mg 8-hourly reduced mean PAP by -6.9 mm Hg (95% CI -12.4 to -1.3; p=0.018) compared with placebo. The treatment effect for the higher dose of sildenafil compared with placebo
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