National center for cardiology and internal medicine, Bishkek ( Kyrgyzstan)
Abstract: For a long time, investigations under the initiative of academician M. M. Mirrakhimov (1964 - 2004) used exogenous (hypobaric and high-altitude) hypoxia. The most attractive features of the application of hypoxia at chronic glomerulonephritis (ChGN) are its antihyperlipidemic, antihypertensive, immunomodulating and erythropoiesis-stimulating properties. Development of the new method of treatment for hyperlipidemia in nephrotic ChGN with the separate use of exogenous hypoxia and mevacor, and also their combined application and study of the effects of high-altitude climate on ChGN patients with a urinary syndrome. Two groups of patients with ChGN were studied. In the first group, 51 patients ChGN with NS (?) were surveyed. They were divided into 4 subgroups depending on treatment (of hypobaric hypoxia training, mevacor, combination of hypoxia with mevacor and control). The second group included 17 patients with expressed urinary syndrome and was treated in a high-altitude climate. The duration of the treatment was 28 days. In the first group, the antihyperlipidemic effect of the treatment with hypobaric hy-poxia and with mevacor appeared to be the same (16.1% and 20.1% respectively) and their combined application led to more a expressive effect (26.6%, p < 0.05), when favorable shifts were observed in the greater lipid spectrum. In the second group, the treatment in high-altitude climate led to positive changes in the parameters for red blood cells and immunoglobulin G. Combined use of hypobaric hypoxia and mevacor increases the antihyperlipidem-ic effect of mevacor in ChGN patients with nephrotic syndrome. Treatment in a high-altitude climate stimulates erythropoiesis at ChGN.
Keywords : chronic glomerulonephritis; hypoxia; high altitude.
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