Functional Assessment of Cancer Therapy General FACTG

The Functional Assessment of Chronic Illness Therapy (FACIT) Measurement System is a collection of QoL questionnaires targeting chronic illnesses. The core questionnaire, or FACT-G, was developed by Cella et al. (1993) and is a widely used cancer-specific instrument (Appendix E8). Similar to the EORTC QLQ-C30, the FACIT questionnaires adopt a modular approach and so a number of supplementary modules specific to a tumour type, treatment or condition are available. Non-cancer-specific FACIT questionnaires are also available for other diseases such as HIV infection and multiple sclerosis.

The FACT-G version 4 contains 27 items arranged in subscales covering four dimensions of QoL: physical well-being, social/family well-being, emotional well-being, and functional well-being. Items are rated from 0 to 4. The items are labelled from "not at all" to "very much", which is the same as for the QLQ-C30 but with the addition of a central "somewhat". Some items are phrased negatively, and should be reverse-scored. Subscale scores are derived by summing item responses, and a total score is derived by summing the subscale scores. Version 3 included an additional item after each subscale, enabling patients to weight each domain on an 11-point scale from "not at all" to "very much so". These questions were of the form: "Looking at the above 7 questions, how much would you say your PHYSICAL WELL-BEING affects your quality of life?" A similar set of items is optional for version 4.

Individual questions are phrased in the first person ("I have a lack of energy"), as compared with the QLQ-C30 that asks questions in the second person ("Have you felt weak?"). Both questionnaires relate lo the past week, and both make similar claims regarding validity and sensitivity.

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