The development of colorectal cancer (CRC) in patients with ulcerative colitis (UC) is related to the presence of pancolitis or an active disease, the duration and the severity of the disease. Historical global risk for CRC on UC is about 7.2% after 20 years of disease (Table 1) . In a meta-analysis of 116 studies, Eaden showed that there was an increased risk for developing CRC in patients with UC (Table 2) . Moreover, the risk of CRC is 8 times higher in patients with UC compared with people without UC and this risk is 20 times and 4 times higher in the presence of pancolitis or left-sided colitis respectively .
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