- "Crohn like" lymphocytic infiltrate
- Conspicuous: numerous, big lymphoid aggregates, often with germinal centres, at the periphery of the tumour, located at the external border of muscularis propria.
- Mild: occasional small lymphoid aggregates without germinal centres.
- Absent: rare, small lymphoid aggregates or none. The presence of a lymphoid reaction has been shown to be a favourable prognostic factor [41, 49,
50]. The presence of a lymphoid reaction at the lead ing edge of invasive tumour must be distinguished from an intratumoral lymphocytic infiltrate, which is closely associated with microsatellite instability and medullary architecture.
Was this article helpful?