Invasive Tumour

- "Crohn like" lymphocytic infiltrate

- Conspicuous: numerous, big lymphoid aggregates, often with germinal centres, at the periphery of the tumour, located at the external border of muscularis propria.

- Mild: occasional small lymphoid aggregates without germinal centres.

- Absent: rare, small lymphoid aggregates or none. The presence of a lymphoid reaction has been shown to be a favourable prognostic factor [41, 49,

50]. The presence of a lymphoid reaction at the lead ing edge of invasive tumour must be distinguished from an intratumoral lymphocytic infiltrate, which is closely associated with microsatellite instability and medullary architecture.

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