In several studies, both lymphatic invasion and perineural invasion have been shown by multivariate analysis to be independent indicators of poor prognosis [32, 35, 38-40]. The prognostic significance, if any, of the anatomic location of these structures is not defined. Furthermore, it is not always possible to distinguish lymphatic vessels from postcapillary venules, as both are small, thin-walled structures. Thus, the presence or absence of tumour invasion of small, thin-walled vessels should be reported in all cases and its anatomic location within the colonic wall noted .
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