In patients who underwent a radical resection of both rectal cancer and liver metastases, many prognostic factors were identified and proved to be important in predicting survival (Table 2). All prognostic factors that were proposed require as a necessary condition that both rectal and hepatic resection must be radical (R0) . This condition is associated with a 5-year survival value which may exceed 40%, whereas in the case of non-radical resections, with a microscopic (R1) or macroscopic (R2) residual disease, survival is substantially comparable to palliative therapies, with a 5-year survival of 0-3% .
In 90% of patients, mortality after hepatic curative resection is determined by disease recurrence both at a hepatic and extra-hepatic level. The prognostic factors may be grouped into 3 categories: the patient's, the primitive tumour's and the hepatic metastases' characteristics.
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