Rectal Stump

An important issue is the fate of the rectum after subtotal colectomy for UC or Crohn's disease. Johnson et al. [48] studied a series of 1439 patients with UC. A surgical resection was performed in 374 patients (26%); 172 patients underwent subtotal colectomy with mucous fistula. Ten patients (3.6%) developed a rectal cancer. In this study the cumulative risk of developing a rectal cancer in the rectal stump reached 17% 27 years after disease onset.

A similar study by Oakley et al. [49] on 288 patients having a subtotal colectomy for UC showed four patients (1.4%) who developed a cancer in the rectal stump.

Winther et al. [50] studied 42 patients with a closed rectal stump after surgery for UC or Crohn's disease. The median duration of the disease was 8.3 years (1.3-34 years). The Authors showed no endoscopic or histological signs of dysplasia or carcinoma and no mutation of p53 gene in any biopsy or lavage fluid. However, 78% and 43% of the patients showed moderate to severe mucosal inflammation and rectal stump involution respectively. For this reason a role of adjuvant markers to improve cancer surveillance in this subgroup of patients is advocated.

Was this article helpful?

0 0
Dealing With Erectile Dysfunction

Dealing With Erectile Dysfunction

Whether you call it erectile dysfunction, ED, impotence, or any number of slang terms, erection problems are something many men have to face during the course of their lifetimes.

Get My Free Ebook


Post a comment