Many Authors advise a safe margin of healthy tissue larger than 1 cm [4, 28]. More recently, clinical studies showed that the 1 cm limit, determined by Ekberg in 1987 , is not so imperative. Survival is significantly worse in patients with positive surgical margins, with no survivors after 5 years. But for patients with negative margins, survival is not different for margins greater or smaller than 1 cm, with 5-year survivals of 43% and 37%, respectively . As a consequence, it seems that nowadays it is feasible to perform, especially in the case of multiple metastases, metastases resections with margins lower than 1 cm, as long as R0 surgical radicality is granted.
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