Cell Dedifferentiation and Proliferation

Band Bungner

The distal part of an injured axon is degraded by a process called Wallerian degeneration. The mechanism of Wallerian degeneration is distinct from pathological neurodegenerative processes such as dying back from the target tissue or the pruning process observed during embryonic neurogenesis that matches the proper number of axons to their targets (Raff et al., 2002). During Wallerian degeneration, axons and their myelin layers distal to the injury disintegrate over a period of several days....

Reinnervation of Granulation Tissue

Medical Images Vat Scars

Peripheral sensory and sympathetic postganglionic nerves also regenerate in healing wounds and play a significant role in the formation of granulation tissue FIGURE 2.4 Comparison of collagen organization in normal uninjured dermal architecture (a) vs collagen organization in dermal scar tissue (b). The collagen of the uninjured dermis has a reticular (basket-weave) organization, whereas the collagen in a repaired dermis is cross-linked into thick bundles parallel to the wound surface....