Ephrin And Amphibian Tail And Limb Regeneration

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Aguayo AJ (1985) Axonal regeneration from injured neurons in the adult mammalian central nervous system. In: CW Cotman (ed.). Synaptic Plasticity. New York, Guilford Press, pp 457-483.

Ahmad I, Tang L, Pham H (2000) Identification of neural progenitors in the adult mammalian eye. Biochem Biophys Res Comm 270:517-521.

Alibardi L, Sala M (1988) Fine structure of the blastema in the regenerating tail of the lizard Podarcis sicula. Boll Zool 55:307-313.

Alibardi L, Miolo V (1990) Fine observation on nerves colonizing the regenerating tail of the lizard Podarcis sicula. Histol Histopath 5:387-396.

Alibardi L, Gibbons J, Simpson SB (1992) Fine structure of cells in the young regenerating spinal cord of the lizard Anolis carolin-ensis after H3-thymidine administration. Biol Struct Morph 4:45-52.

Altman J (1962) Are new neurons formed in the brains of adult mammals? Science 135:1127-1128.

Altman J (1963) Autoradiographic investigation of cell proliferation in the brains of rats and cats. Anat Rec 145:573-591.

Altmann CR, Brivanlou AH (2001) Neural patterning in the vertebrate embryo. Int Rev Cytol 203:447-482.

Anton ES, Sandrock AW, Matthew WD (1994) Merosin promotes neurite outgrowth and Schwann cell migration in vitro: Evidence using an antibody to merosin, ARM-1. Dev Biol 164: 133-146.

Arsanto J-P, Komorowski TE, Dupin F, Caubit X, Diano M, Geraudie J, Carlson BM, Thouveny Y (1992) Formation of the peripheral nervous system during tail regeneration in urodele amphibians: Ultrastructure and immunohistochemical studies of the origin of the cells. J Exp Zool 264:273-292.

Arsenijevic Y, Taverney N, Kostic C, Tekaya M, Riva F, Zografos L, Schorderet D, Munier F (2003) Non-neural regions of the adult human eye: A potential source of neurons? Invest Opthalmol Vis Sci 44:799-807.

Ashmore J, Gale J (2000) The cochlea. Curr Biol 10:R325-R327.

Attardi DG, Sperry RW (1963) Preferential selection of central pathways by regenerating optic nerve fibers. Exp Neurol 7:4664.

Barron KD (1983) Axon reaction and central nervous system regeneration. In: Seil FJ (ed.). Nerve, Organ and Tissue Regeneration: Research Perspectives. New York, Academic Press, pp 3-36.

Beck CW, Slack JMW (1998) Analysis of the developing Xenopus tail bud reveals separate phases of gene expression during determination and outgrowth. Mech Dev 72:41-52.

Beck CW, Christen B, Slack JMW (2003) Molecular pathways needed for regeneration of spinal cord and muscle in a vertebrate. Dev Cell 5:429-439.

Becker CG, Becker T, Meyer RL, Schachner M (1999) Tenascin-R inhibits the growth of optic fibers in vitro but is rapidly eliminated during nerve regeneration in the salamander Pleurodeles waltl. J Neurosci 19:813-827.

Benraiss A, Caubit X, Coulon J, Nicolas S, Le Parco Y, Thouveny Y (1996) Clonal cell cultures from adult spinal cord of the amphibian urodele Pleurodeles waltl to study the identity and potentialities of cells during tail regeneration. Dev Dynam 205: 135-149.

Benraiss A, Arsanto JP, Coulon J, Thouveny Y (1997) Neural crestlike cells originate from the spinal cord during tail regeneration in adult amphibian urodeles. Dev Dynam 209:15-28.

Benraiss A, Arsanto JP, Coulon J, Thouveny Y (1999) Neurogenesis during caudal spinal cord regeneration in adult newts. Dev Genes Evol 209:363-369.

Bermingham-McDonough O, Stone JS, Reh TA, Rubel EW (2001) FGFR3 expression during development and regeneration of the chick inner ear sensory epithelia. Dev Biol 238:247-259.

Benson MD, Romero MI, Lush ME, Lu QR, Henkemeyer M, Parada LF (2005) Ephrin-B3 is a myelin-based inhibitor of neurite outgrowth. Proc Natl Acad Sci USA 102:10694-10699.

Birling M-C, Price J (1995) Infuence of growth factors on neuronal differentiation. Curr Opinion Cell Biol 7:878-884.

Bisby MA (1995) Regeneration of peripheral nervous system axons. In: Waxman SG, Kocsis J, Stys PK (eds.). The Axon: Structure, Function and Pathophysiology. New York, Oxford University Press, pp 553-578.

Bodega G, Suarez I, Rubio M, Fernandez B (1994) Ependyma: Phylogenetic evolution of glial fibrillary acidic protein (GFAP) and vimentin expression in vertebrate spinal cord. Histochem 102:113-122.

Bohn R, Reier PJ, Sourbeer EB (1982) Axonal interactions with connective tissue and glial substrata during optic nerve regeneration in Xenopus larvae and adults. Am J Anat 165:397-419.

Bottai D, Fiocco R, Gelain F, Defilippis L, Galli R, Gritti A, Vescovi AL (2003) Neural stem cells in the adult nervous system. J Hematother Stem Cell Res 12:655-670.

Boucher S-EM, Hitchcock PF (1995) Insulin-related factors stimulate in vitro proliferation of pluripotent neuroepithelial cells, but not rod precursors or injury-induced progenitors, in adult goldfish retina. Soc Neurosci 21:1557 (abstract).

Branda CS, Dymecki SM (2004) Talking about a revolution: The impact of site-specific recombinases on genetic analyses in mice. Dev Cell 6:7-28.

Briscoe J, Ericson J (2001) Specification of neuronal fates in the ventral neural tube. Curr Opin Neurobiol 11:43-49.

Bunge R (1987) Tissue culture observations relevant to the study of axon-Schwann cell interactions during peripheral nerve development and repair. J Exp Biol 132:21-34.

Butler EG, Ward MB (1965) Reconstitution of the spinal cord following ablation in urodele larvae. J Exp Zool 160:47-66.

Butler EG, Ward MB (1967) Reconstitution of the spinal cord following ablation in adult Triturus. Dev Biol 15:464-486.

Capela A, Temple S (2002) LeX/SSEA-1 is expressed by adult mouse CS stem cells, identifying them as nonependymal. Neuron 35:865-875.

Caroni P, Schwab ME (1988) Two membrane protein fractions from rat central myelin with inhibitory properties for neurite growth and fibroblast spreading. J Cell Biol 106:1281-1288.

Caubit X, Arsanto J-P, Figarella-Branger D, Thouveny Y (1993) Expression of polysialylated neural cell adhesion molecule (PSA-N-CAM) in developing, adult and regenerating caudal spinal cord of the urodele amphibians. Intl J Dev Biol 37:327-336.

Caubit X, Riou JF, Coulon J, Arsanto JP, Benraiss A, Boucaut JC, Thouveny Y (1994) Tenascin expression in developing, adult and regenerating caudal spinal chord in the urodele amphibians. Intl J Develop Biol 38:661-672.

Caubit X, Nicolas S, Shi DL, Le Parco Y (1997a) Reactivation and graded axial expression pattern of Wnt-10a gene during early regeneration stages of adult tail in amphibian urodele Pleurodeles waltl. Dev Dyn 208:139-148.

Caubit X, Nicolas S, Le Parco Y (1997b) Possible roles for Wnt genes in growth and axial patterning during regeneration of the tail in urodele amphibians. Dev Dyn 210:1-10.

Chen P, Segil N (1999) p27(kip1) links cell proliferation to morphogenesis in the developing organ of Corti. Development 126:15811590.

Chen MS, Huber AB, Can der Haar ME, Fran M, Schnell L, Spillmann AA, Christ F, Schwab ME (2000) Nogo-A is a myelin-associated neurite outgrowth inhibitor and an antigen for monoclonal antibody IN-1. Nature 403:434-439.

Chernoff EAG, O'Hara CM, Bauerle D, Bowling M (2000) Matrix metalloproteinase production in regenerating axolotl spinal cord. Wound Rep Reg 8:282-291.

Chernoff EAG, Stocum DL, Nye HLD, Cameron JA (2003) Urodele spinal cord regeneration and related processes. Dev Dynam 226:280-294.

Cho K-S, Yang L, Lu B, Ma HF, Huang X, Pekny M, Chen DF (2005) Re-establishing the regenerative potential of central nervous system axons in postnatal mice. J Cell Sci 118:863-872.

Chong JA, Tapia-Ramirez J, Kim S, Toledo-Aral JJ, Zheng Y, Boutros MC, Aktshuller YM, Frohman MA, Kraner SD, Mandel G (1995) REST: A mammalian silencer protein that restricts sodium channel gene expression to neurons. Cell 80:949-957.

Chuah MI, Au C (1991) Olfactory Schwann cells are derived from precursor cells in the olfactory epithelium. J Neuro Sci Res 29: 172-180.

Clarke JDW, Alexander R, Holder N (1988) Regeneration of descending axons in the spinal cord of the axolotl. Neruosci Lett 89:1-6.

Clarke JDW, Ferretti P (1998) CNS regeneration in lower verte-brtates. In: Ferretti P, Geraudie J (eds.). Cellular and Molecular Basis of Regeneration. New York, John Wiley and Sons, pp 255-272.

Cohen SM, Jurgens G (1989) Proximal-distal pattern formation in Drosophila: Cell autonomous requirement for distal-less gene activity in limb development. EMBO J 8:2045-2055.

Cohen A, Sivron T, Duvdedani R, Schwartz M (1990) Oligoden-drocyte cytotoxic factor associated with fish optic nerve regenera tion: implications for mammalian CNS regeneration. Brain Res 537:24-32.

Coles BLK, Angenieux B, Inoue T, Del Rio-Tsonis K, Spence JR, McInnes RR, Arsenijevic Y, van der Kooy D (2004) Facile isolation and the characterization of human retinal stem cells. Proc Natl Acad Sci USA 101:15772-15777.

Cotanche DA, Lee KH, Stone JS, Picard DA (1994) Hair cell regeneration in the bird cochlea following noise damage or ototoxic drug damage. Anat Embryol Berlin 189:1-18.

Coulombre JL, Columbre AJ (1965) Regeneration of neural retina from the pigmented epithelium in the chick embryo. Dev Biol 12:79-92.

Coulombre JL, Coulombre AJ (1970) Influence of mouse neural retina on regeneration of chick neural retina from chick embryonic pigmented epithelium. Nature 228:559-560.

Cotanche DA (1987) Regeneration of hair cell stereociliary bundles in the chick cochlea following severe acoustic trauma. Ear Res 30:181-194.

Croce CM, Calin GA (2005) Archeo-cell biology: Carbon dating is not just for pots and dinosaurs. Cell 122:4-7.

Davies AM (2000) Neurotrophins: neurotrophic modulation of neurite growth. Curr Biol 10:R198-R200.

Davis BM, Duffy MT, Simpson, SB Jr (1989) Bulbospinal and intraspinal connection in normal and regenerated salamander spinal cord. Exp Neurol 103:41-51.

Davis BM, Ayers JL, Koran L, Carlson J, Anderson MC, Simpson SB (1990) Time course of salamander spinal cord regeneration and recovery of swimming: HRP retrograde pathway tracing and kinematic analysis. Exp Neurol 108:198-213.

Dickson BJ (2002) Molecular mechanisms of axon guidance. Science 298:1959-1964.

Doetsch F, Caille I, Lim DA, Garcia-Verdugo JM, Alvarez-Bullya A (1999) Subventricular zone astrocytes are neural stem cells in the adult mammalian brain. Cell 97:703-716.

Doherty P, Walsh FS (1991) The contrasting roles of N-CAM and N-cadherin as neurite outgrowth-promoting molecules. J Cell Sci 15 (Suppl):13-21.

Duffy MT, Liebich DR, Garner LK, Hawrych A, Simpson SB Jr, Davis BM (1992) Axonal sprouting and frank regeneration in the lizard tail spinal cord:correlation between changes in synaptic circuitry and axonal growth. J Comp Neurol 316:363-374.

Echeverri K, Tanaka EM (2002) Ectoderm to mesoderm lineage switching during axolotl tail regeneration. Science 298:19931996.

Edwards DL, Alpert R, Grafstein B (1981) Recovery of vision in regeneration of goldfish optic axons: enhancement of axonal outgrowth by a conditioning lesion. Exp Neurol 72:672-686.

Egar M, Singer M (1972) The role of ependyma in spinal cord regeneration in the urodele, Triturus. Exp Neurol 37:422-430.

Egar M, Singer M (1981) The role of ependyma in spinal cord regrowth. In: Becker RO (ed.). Mechanisms of Growth Control. Springfield, Charles Thomas, pp 93-106.

Eitan S, Schwartz M (1993) A transglutaminase that converts interleulin-2 into a factor cytotoxic to oligodendrocytes. Science 261:106-108.

Eng LF, Reier PJ, Houle JD (1987) Astrocyte activation and fibrous gliosis: Glial fibrillary acidic protein immunostaining of astro-cytes following intraspinal cord grafting of fetal CNS tissue. Prog Brain Res 71:439-455.

Eriksson PS, Perfilieva E, Bjork-Eriksson T, Alborn AM, Nordberg C, Peterson DA, Gage FH (1998) Neurogenesis in the adult hippocampus. Nature Med 4:1313-1317.

Eser P, Schiessl H, Willnecker J (2004) Bone loss and steady state after spinal cord injury: A cross-sectional study using pQCT. J Musculoskel Neuron Interact 4:197-198.

Farlow DN, Vansant G, Cameron A, Chang J, Khoh-Reiter S, Pham N-L, Wu W, Sagara Y, Nicholls JG, Carlo DJ, 1ll, CR (2000) Gene expression monitoring for gene discovery in models of peripheral and central nervous system differentiation, regeneration, and trauma. J Cellular Biochem 80:171-180.

Fawcett JW, Asher RA (1999) The glial scar and central nervous system repair. Brain Res Bull 49:377-391.

Fekete DM (1996) Cell fate specification in the inner ear. Curr Opin Neurobiol 6:533-541.

Fekete DM, Wu DK (2002) Revisiting cell fate specification in the inner ear. Curr Opin Neurobiol 12:35-42.

Ferretti P, Zhang F, O'Neill P (2003) Changes in spinal cord regenerative ability through phylogenesis and development. Dev Dynam 226:245-256.

Filbin MT (2000) Axon regeneration: Vaccinating against spinal cord injury. Curr Biol 10:R100-103.

Fischer AJ, Seltner RLP, Poon J, Stell WK (2001) Muller glia are a potential source of neural regeneration in the post-natal chicken retina. Nat Neurosci 4:247-252.

Fischer AJ, Reh TA (2002) Exogenous growth factors stimulate the regeneration of ganglion cells in the chicken retina. Dev Biol 251:367-379.

Fischer AJ, Dierks BD, McGuire C, Reh TA (2002) Insulin and FGF2 activate a neurogenic program in Muller glia of the chicken retina. J Neurosci 22:9387-9398.

Fischer AJ, Reh TA (2003a) Potential of Muller glia to become neurogenic retinal progenitor cells. Glia 43:70-76.

Fischer AJ, Reh TA (2003b) Growth factors induce neurogenesis in the ciliary body. Dev Biol 259:225-240.

Forge A, Li L, Corwin JT, Nevill G (1993) Ultrastructural evidence for hair cell regeneraton in the mammalian inner ear. Science 25:1616-1619.

Fu SY, Gordon T (1997) The cellular and molecular basis of peripheral nerve regeneration. Mol Neurobiol 14:67-116.

Gage FH (2000) Mammalian neural stem cells. Science 287:14331438.

Garrity PA, Zipursky SL (1995) Neuronal target recognition. Cell 83:177-185.

Gaze RM (1959) Regeneration of the optic nerve in Xenopus laevis. Quart J Exp Physiol 44: 209-308.

Gaze M, Grant P (1978) The diencephalic course of regenerating retinotectal fibers in Xenopus tadpoles. J Embryol Exp Morph 44:201-216.

Geraudie J, Nordlander R, Singer M, Singer J (1988) Early stages of spinal ganglion formation during tail regeneration in the newt, Notophthalmus viridescens. Am J Anat 183:359-370.

Go MJ, Eastman DS, Artavanis-Tsakonas S (1998) Cell proliferation control by Notch signaling in Drosophila development. Development 125:2031-2040.

Goh ELK, Ma D, Ming G-L, Song H (2003) Adult neural stem cells and repair of the adult central nervous system. J Hematother Stem Cell Res 12671-679.

Goldman SA, Nottebohm F (1983) Neuronal production, migration, and differentiation in a vocal control nucleus of the adult female canary brain. Proc Natl Acad Sci USA 80:2390-2394.

Goodrum JF, Bouldin TW (1996) The cell biology of myelin degeneration and regeneration in the peripheral nervous system. J Neuropath Exp Neurol 55:943-953.

Gould E, Tanapat P (1997) Lesion-induced proliferaton of neuronal progenitors in the dentate gyrus of the adult rat. Neurosci 80: 427-436.

Gould E, Tanapat P, McEwen BS, Flugge G, Fuchs E (1998) Proliferation of granule cell precursors in the dentate gyrus of adult monkeys is diminished by stress. Proc Natl Acad Sci USA 95:3168-3171.

Gould E, Reeves AJ, Graziano MSA, Gross CG (1999) Neurogenesis in the neocortex of adult primates. Science 286:548-552.

Grafstein B (1983) Chromatolysis reconsidered: A new view of the reaction of the nerve cell body to axon injury. In: Seil FC (ed.). Nerve, Organ and Tissue Regeneration: Research Perspectives. New York, Academic Press, pp 37-50.

Grafstein B (1991) The goldfish visual system as a model for the stdy of regeneraton in the central nervous system. Development and plasticity of the visual system. In: Cronley-Dillon JR (ed.). Vision and Visual Dysfunction Vol II. London, Macmillan, pp 190205.

GrandPre T, Nakamura F, Vartanian T, Strittmatter SM (2000) Identification of the nogo inhibitor of axon regeneration as a reticulon protein. Nature 403:439-443.

GrandPre T, Li S, Strittmatter SM (2002) Nogo-66 receptor antagonist peptide promotes axonal regeneration. Nature 417:547555.

Grant P, Tseng Y (1986) Embryonic and regenerating Xenopus retinal fibers are intrinsically different. Dev Biol 114:475491.

Guena S, Borrione P, Fornaro M, Giacobini-Robecchi MG (2001) Adult stem cells and neurogenesis: historical roots and state of the art. Anat Rec 265:132-141.

Haddon C, Smithers L, Schneider-Maunoury S, Coche T, Henrique D, Lewis J (1998a) Multiple Delta genes and lateral inhibition in zebrafish primary neurogenesis. Development 125:359-370.

Haddon C, Jiang Y-J, Smithers L, Lewis L (1998b) Delta-Notch signaling and the patterning of sensory cell differentiation in the zebrafish ear: Evidence from the mind bomb mutant. Development 125:4645-4654.

Ham AW, Cormack DH (1979) Histology, 8th ed. Philadelphia, JB Lippincott, pp 614-644.

Haruta M, Kosaka M, Kanagae Y, Saito I, Inoue T, Kageyama R, Nishida A, Honda Y, Takahashi M (2001) Induction of photore-ceptor-specific phenotypes in adult mammalian iris tissue. Nature Neurosci 4:1163-1164.

Hasan SJ, Nelson BH, Valenzuela JL, Kierstead HS, Shull SE, Ethell DW, Steeves JD (1991) Functional repair of transected spinal cord in embryonic chick. Restor Neurol Neurosci 2:137154.

Haynes T, Del-Rio Tsonis K (2004) Retina repair, stem cells and beyond. Curr Neurovasc Res 1:1-8.

Hitchcock PF, Raymond PA (1992) Retinal regeneration. Trends in Neurosci 15:103-108.

Hitchcock PF, Lindsey KJ, Easter SS Jr, Mangione-Smith R, Jones DD (1992) Local regeneration in the retina of the goldfish. J Neurobiol 23:187-203.

Holder N, Clarke JDW (1988) Is there a correlation between continuous neurogenesis and directed axon regeneration in the vertebrate nervous system? Trends Neurosci 11:94-99.

Holder N, Clarke JDW, Wilson S, Hunter K, Tonge DA (1989) Mechanisms controlling directed axon regeneration in the peripheral and central nervous systems of amphibians. In: Kiorstsis V, Koussoulakos S, Wallace H (eds.). Recent Trends in Regeneration Research, NATO ASI Series 172:179-190.

Holder N, Clarke JDW, Kamalati T, Lane EB (1990) Heterogeneity in spinal radial glia demonstrated by intermediate filament expression and HRP labeling. J Neurocytol 19:915-928.

Holder N, Clarke JDW, Stephens,N, Wilson SW, Orsi C, Bloomer T, Tonge DA (1991) Continuous growth of the motor system in the axolotl. J Comp Neurol 303:534-550.

Holtzer H (1952) Reconstitution of the urodele spinal cord following unilateral ablation. J Exp Zool 119:263-301.

Horner PJ, Gage FH (2000) Regenerating the damaged central nervous system. Nature 407:963-969.

Huang DW, McKerracher L, Braun PE, David M (1999) A therapeutic vaccine approach to stimulate axon regeneration in the adult mammalian spinal cord. Neuron 24:639-647.

Hunter K, Tonge DA, Holder N (1988) In vitro neurite outgrowth from axolotl neurons. Neurosci Lett (Suppl) 32:S68.

Hunter K, Maden M, Summerbell D, Eriksson U, Holder N (1991) Retinoic acid stimulates neurite outgrowth in the amphibian spinal cord. Proc Natl Acad Sci USA 88:3666-3670.

Hynes M, Rosenthal A (1999) Specification of dopaminergic and serotoergic neurons in the vertebrate CNS. Curr Opinion Neurobiol 9:26-36.

Imokawa Y, Brockes JP (2003) Selective activation of thrombin is a critical determinant for vertebrate lens regeneration. Curr Biol 13:877-881.

Iwashita Y, Kawaguchi S, Murata ME (1994) Restoration of function by replacement of spinal cord segments in the rat. Nature 367167-170.

Jensen AM, Wallace VA (1997) Expression of Sonic hedgehog and its putative role as a precursor cell mitogen in the developing mouse retina. Development 124:363-371.

Jimeno D, Lillo C, Cid E, Aijon J, Velasco A, Lara JM (2003) The degenerative and and regenerative processes after elimination of the proliferative peripheral retina in fish. Exp Neurol 179: 210-218.

Jin K, Minami M, Lan JQ, Mao XO, Batteur S, Simon RP, Greenberg DA (2001) Neurogenesis in dentate subgranular zone and rostral subventricular zone after focal cerebral ischemia in the rat Proc Natl Acad Sci USA 98:4710-4715.

Johansson C, Momma S, Clarke D, Risling M, Lendahl U, Frisen J (1999) Identification of a neural stem cell in the adult mammalian central nervous system. Cell 96:25-34.

Jones JE, Corwin JT (1996) Regeneration of sensory cells after laser ablation in the lateral line system: Hair cell lineage and macrophage behavior revealed by time-lapse video microscopy. J Neurosci 16:649-662.

Julian D, Ennis K, Korenbrot JL (1998) Birth and fate of prolifera-tive cells in the inner nuclear layer of the mature fish retina. J Comp Neurol 394:271-282.

Kapfhammer JP, Schwab ME (1992) Modulators of neuronal migration and neurite growth. Curr Opinion Cell Biol 4:863-868.

Keefe JR (1973a) An analysis of urodelan retinal regeneration: I. Studies of the cellular source of retinal regeneration in Notopthalmus viridescens utilizing 3H-thymidine and colchicines. J Exp Zool 184:185-206.

Keefe JR (1973b) An analysis of urodelan retinal regeneration: II. Ultrastructural features of retinal regeneration in Notophthalmus viridescens. J Exp Zool 184:207-232.

Keefe JR (1973c) An analysis of urodelan retinal regeneration: III. Degradation of extruded melanin granules in Notopthalmus viridescens. J Exp Zool 184:233-238.

Kehl LJ, Fairbanks CA, Laughlin TM, Wilcox GL (1997) Neurogenesis in postnatal rat spinal cord: A study in primary culture. Science 276:586-589.

Kelley MW, Xu X-M, Wagner MA, Warchol ME, Corwin JT (1993) The developing organ of Corti contains retinoic acid and forms supernumerary hair cells in response to exogenous retinoic acid in culture. Development 119:1041-1053.

Kempermann G, Kuhn HG, Gage FH (1998) Experience-induced neurogenesis in the senescent dentate gyrus. J Neurosci 18: 3206-3212.

Kierstead HS, Dyer JK, Sholomenko G, McGraw J, Delaney KR, Steeves JD (1995) Axonal regeneration and physiological activity following transection and immunological disruption of myelin within the hatchling chick spinal cord. J Neurosci 15:69636974.

Kil J, Warchol ME, Corwin JT (1997) Cell death, cell proliferation, and estimates of hair cell life spans in the vestibular organs of chicks. Hear Res 114:117-126.

Klein LR, MacLeish PR, Wiesel TN (1990) Immunolabeling by a newt retinal pigment epithelium antibody during retinal development and regeneration. J Comp Neurol 293:331-339.

Kornack D, Rakic P (2001) Cell proliferation without neurogenesis in adult primate neocortex. Science 294:2127-2130.

Kuwabara T, Hsieh J, Nakashima K, Taita K, Gage FH (2004) A small modulatory dsRNA specifies the fate of adult neural stem cells. Cell 116:779-793.

Lang DM, Rubin BP, Schwab ME, Stuermer CA (1995) CNS myelin and oligodendrocytes of the Xenopus spinal cord—but not optic nerve—are nonpermissive for axon growth. Neurosci 15:99109.

Lefcourt F, Venstrom K, McDonald JA, Reichardt LK (1992) Regulation of expression of fibronectin and its receptor, ^ßx, during development and regeneration of peripheral nerve. Development 116:767-782.

Lefebvre P, Malgrange B, Staecker H, Moonen G, Van De Water R (1993) Retinoic acid stimulates regeneration of mammalian auditory hair cells. Science 260:692-695.

Levine R (1977) Regeneration of the retina in the adult newt, Triturus cristatus, following surgical division of the eye by a post-limbal incision. J Exp Zool 200:41-54.

Litzinger TC, Del-Rio Tsonis K (2002) Eye anatomy. Encyclopedia of Life Sciences, MacMillan Publishers Ltd, Nature Publishing Group, pp 1-7.

Liu J, Solway K, Messing RO, Sharp FR (1998) Increased neurogen-esis in the dentate gyrus after transient global ischemia in gerbils. J Neurosci 18:7768-7778.

Liu S, Qu Y, Stewart J, Howard MJ, Chakraborty S, Holekamp F, McDonald JW (2000) Embryonic stem cells differentiate into oligodendrocytes and myelinate in culture and after spinal cord transplantation. Proc Natl Acad Sci USA 97:6126-6131.

Livesey FJ, O'Brien A, Li M, Smith AG, Murphy LJ, Hunt SP (1997) A Schwann cell mitogen accompanying regeneration of motor neurons. Nature 390:614-618.

Lois C, Alvarez-Buylla A (1994) Long-distance neuronal migration in the adult mammalian brain. Science 264:1145-1148.

Lois C, Garcia-Verdugo JM, Alvarez-Buylla A (1996) Chain migration of neuronal precursors. Science 271:978-981.

Louissaint A Jr, Rao S, Leventhal C, Goldman SA (2002) Coordinated interaction of neurogenesis and angiogenesis in the adult songbird brain. Neuron 34:945-960.

Lowenheim H (2000) Regenerative biology of hearing: Taking the brakes off the cell cycle engine. J Reg Med (e-biomed) 1:2124.

Lowenheim H, Furness DN, Kil J, Zinn C, Gultig K, Fero ML, Frost D, Gummer AW, Roberts JM, Rubel EW, Hackney C, Zenner HP (1999) Gene disruption of a p27 (Kip 1) allows cell proliferation in the postnatal and adult organ of Corti. Proc Nat Acad Sci USA 96:4084-4088.

Lu J, Waite P (1999) Advances in spinal cord regeneration. Spine 24:926-930.

Luskin M, Parnavelas JG, Barfield JA (1993) Neurons, astrocytes, and oligodendrocytes of the rat cerebral cortex originate from separate progenitor cels: an ultrastructural analysis of clonally related cells. J Neurosci 13:1730-1750.

Magavi SS, Leavitt BR, Macklis JD (2000) Induction of neurogen-esis in the neocortex of adult mice. Nature 405:951-955.

Maier W, Wolburg H (1979) Regeneration of the goldfish retina after exposure to different doses of oubain. Cell Tiss Res 202:99-118.

Matthey R (1925) Recuperation de la vue après resection des nerfs optiques, chez le Triton. Comp Rend Soc Biol 93:904-906.

McCachren SS, Lightner V (1992) Expression of human tenascin in synovitis and its regulation by interleukin-1. Arthritis Rheum 35:1185-1196.

McDonald JW, Sadowsky C (2002) Spinal cord injury. The Lancet 359:417-425.

McKay R (1997) Stem cells in the central nervous system. Science 276:66-71.

McQuarrie IG (1983) Role of the axonal cytoskeleton in the regenerating nervous system. In: Seil FJ (ed.). Nerve, Organ and Tissue Regeneration: Research Perspectives. New York, Academic Press, pp 51-88.

McQuarrie IG, Lasek RJ (1989) Transport of cytoskeletal elements from parent axons into regenerating daughter axons. J Neurosci 9:436-446.

Mendoza AS, Breipohl W, Miragall F (1982) Cell migration from the chick olfactory placode: A light and electron microscopic study. J Embryol Exp Morph 69:47-59.

Messier B, LeBlond CP, Smart I (1958) Presence of DNA synthesis and mitosis in the brain of young adult mice. Exp Cell Res 14:224-226.

Miller RH, Liuzzi FJ (1986) Regional specialization of the radial glial cells of the adult frog spinal cord. J Neurocytol 15:187196.

Mitashov VI (1996) Mechanisms of retina regeneration in urodeles. Int J Dev Biol 40:833-844.

Mocchetti I, Rabin S, Colangelo AM, Whittemore SR, Wrathall JR (1996) Increased basic fibroblast growth factor expression following contusive spinal cord injury. Exp Neurol 141:154-164.

Momma S, Johansson SB, Frisen J (2000) Get to know your stem cells. Curr Opinion Neurobiol 10:45-49.

Moshiri A, Reh TA (2004) Persistent progenitors at the retinal margin of ptc+'- mice. J Neurosci 24:229-237.

Nakamura Y, Sakakibara S, Miyata T, Ogawa M, Shimazaki T, Weiss S, Kageyama R, Okano H (2000) The bHLH gene hes 1 as a repressor of the neuronal commitment of CNS stem cells. J Neurosci 20:283-293.

Nakatomi H, Toshihiko Kuriu, Okabe S, Yamamoto S, Hatano O, Kawahara N, Tamura A, Kirino T, Nakafuku M (2002) Regeneration of hippocampal pyramidal neurons after ischemic brain injury by recruitment of endogenous neural progenitors. Cell 110:429-441.

Nakayama K, Nakayama K (1998) Cip'Kip cyclin-dependent kinase inhibitors: brakes of the cell cycle engine during development. Bioessays 20:1020-1029.

Negeshi K, Shinagawa S, Ushijima M, Kaneko Y, Saito T (1992) An immunohistochemical study of regenerating newt retinas. Dev Brain Res 68:255-264.

Nicholls J, Saunders N (1996) Regeneration of immature mammalian spinal cord after injury. Trends Neurosci 19:229-234.

Nicolas S, Caubit X, Massacrier A, Cau P, Le Parco, Y (1999) Two Nkx-3-related genes are expressed in the adult and regenerating central nervous system of the urodele Pleurodeles waltl. Dev Genet 24:319-328.

Nicolas S, Massacrier A, Caubit X, Cau P, Le Parco Y (1996) A distal-less-like gene is induced in the regenerating central nervous system of the urodele Pleurodeles waltl. Mech Dev 56:209-220.

Niederost B, Zimmerman DR, Schwab ME, Bandtlow CE (1999) Bovine CNS myelin contains neurite growth-inhibitory activity associated with chondroitin sulfate proteoglycans. J Neurosci 19:8979-9889.

Noji S, Matsuo T, Koyama E, Yamaai T, Nohno T, Matsuo N, Tanaguchi S (1990) Expression pattern of acidic and basic fibro-blast growth factor genes in adult rat eyes. Biochem Biophys Res Comm 168:343-349.

Nordlander R, Singer M (1978) The role of ependyma in regeneration of the spinal cord in the urodele amphibian tail. J Comp Neurol 180:349-374.

Oesterle EC, Rubel EW (1996) Hair cell regeneration in vestibular sensory epithelia. Ann NY Acad Sci 781:34-70.

O'Hara CM, Egar MW, Chernoff EAG (1992) Reorganization of the ependyma during axolotl spinal cord regeneration: Changes in intermediate filament and fibronectin expression. Dev Dynam 193:103-115.

O'Hara CM, Chernoff EAG (1994) Growth factor modulation of injury-reactive ependymal cell proliferation and migration. Tissue and Cell 26: 599-611.

O'Neill P, Whalley K, Ferretti P (2004) Nogo and Nogo-66 receptor in human and chick: implications for development and regeneration. Dev Dynam 231:109-121.

Orts-Llorca F, Genis-Galvez JM (1960) Experimental production of retinal septa in the chick embryo: Differentiation of pigment epithelium into neural retina. Acta Anat 42:31-70.

Otteson DC, D'Costa AR, Hitchcock PF (2001) Putative stem cells and the lineage of rod photoreceptors in the mature retina of the goldfish. Dev Biol 232:62-76.

Otteson DC, Hitchcock PF (2003) Stem cells in the teleost retina: Persistent neurogenesis and injury-induced regeneration. Vision Res 43:927-936.

Palmer TD, Willhoite AR, Gage FH (2000) Vascular niche for adult hippocampal neurogenesis. J Comp Neurol 425:479-494.

Park C, Hollenberg MJ (1991) Induction of retinal regeneration in vivo by growth factors. Dev Biol 148:322-333.

Park C, Hollenberg MJ (1993) Growth factor-induced retinal regeneration in vivo. Intl Rev Cytol 146:49-71.

Parker SB, Eichele G, Zhang P, Rawls A, Sands AT, Bradley A, Olson EN, Harper JW, Elledge SJ (1995) p53-independent expression of p21Cip1 in muscle and other terminally differentiating cells. Science 267:1024-1027.

Paton A, Nottebohm FN (1984) Neurons generated in the adult brain are recruited into functional circuits. Science 225:10461048.

Pearson CAD, Shibabhara S, Hofsteenge J, Chiquet-Ehrismann R (1988) Tenascin: cDNA cloning and induction by TGF-beta. EMBO J 7:2977-2982.

Perron M, Kanekar S, Vetter ML, Harris WA (1998) The genetic sequence of retinal development in the ciliary margin of the Xenopus eye. Dev Biol 99:185-200.

Piatt J (1955) Regeneration of the spinal cord in the salamander. J Exp Zool 129:177-208.

Pittack C, Jones M, Reh TA (1991) Basic fibroblast growth factor induces retinal pigment epithelium to generate neural retina in vitro. Development 113:577-588.

Pittack C, Grunwald GB, Reh TA (1997) Fibroblast growth factors are necessary for neural retina but not pigmented epithelium differentiation in chick embryos. Development 124:805816.

Prinjha R, Moore SE, Vinson M, Blake S, Morrow R, Christie G, Michalovich D, Simmons DL, Walsh FS (2000) Inhibitor of neurite outgrowth in humans. Nature 403:383-384.

Raff MC, Whitmore AV, Finn JT (2002) Axonal self-destruction and neurodegeneration. Science 296:868-871.

Raivich G, Kreutzberg GW (1993) Peripheral nerve regeneration: Role of growth factors and their receptors. Int J Dev Neurosci 11:311-324.

Ramon-Cueto A, Valverde F (1995) Olfactory bulb ensheathing glia: A unique cell type with axonal growth-promoting properties. Glia 14:163-173.

Rao MS (1999) Multipotent and restricted precursors in the central nervous system. Anat Rec 257:137-148.

Raymond PA, Hitchcock PF (1997) Retinal regeneration: Common principles but a diversity of mechanisms. Adv in Neurol 72:171-184.

Raymond PA, Hitchcock PF (2000) How the neural retina regenerates. Results Problems Cell Diff 31:197-218.

Reh TA, Nagy Y (1987) A possible role for the vascular membrane in retinal regeneration in Rana catesbiena tadpoles. Dev Biol 122:460-482.

Reh TA, Nagy T, Gretton H (1987) Retinal pigment epithelial cells induced to transdifferentiate to neurons by laminin. Nature 330:68-71.

Reier PJ (1979) Penetration of grafted astrocytic scars by regenerating optic nerve axons in Xenopus tadpoles. Brain Res 164:6168.

Reier PJ, Webster H deF (1974) Regeneration and remyelination of Xenopus tadpole optic nerve fibers following transection or crush. J Neurocytol 3:591-618.

Reyer RW (1977) The amphibian eye: Development and regeneration. In: Crescitelli F (ed.), Handbook of Sensory Physiology, Vol. VII/5. Berlin, Springer-Verlag, pp 309-390.

Reynolds B, Weiss S (1992) Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system. Science 255:1707-1710.

Reynolds BA, Weiss S (1996) Clonal and population analyses demonstrate that an EGF-responsive mammalian embryonic CNS precursor is a stem cell. Dev Biol 175:1-13.

Rietze RL, Valcanis H, Brooker G, Thomas T, Voss AK, Bartlett PF (2001) Purification of a pluripotent neural stem cell from the adult mouse brain. Nature 412:736-739.

Roberson DF, Rubel EW (1995) Hair cell regeneration. Curr Opin Otolaryngol Head Neck Surg 3:302-307.

Rogers SL, Letourneau PC, Palm SL, McCarthy J, Furcht LT (1983) Neurite extension by peripheral and central nervous system neurons in response to substratum-bound fibronectin and laminin. Dev Biol 98:212-220.

Roy NS, Wang, Jiang L, Kang J, Benraiss A, Harrison P, Restelli C, Fraser R, Couldwell WT, Kawaguchi A, Okano H, Nedergaard M, Goldman SA (2000) In vitro neurogenesis by progenitor cells isolated from the adult human hippocampus. Nat Med 6:271277.

Rungger-Brandle E, Achtstatter T, Franke W (1989) An epithelium-type cytoskeleton in a glial cell: Astrocytes of amphibian optic nerves contain cytokeratin filaments and are connected by desmo-somes. J Cell Biol 109:705-716.

Sage C, Huang M, Karimi K, Gutierrez G, Vollrath MA, Zhang D-S, Garcia-Anoveros J, Hinds PW, Corwin JT, Corey DP, Chen Z-Y (2005) Proliferation of functional hair cells in vivo in the absence of the retinoblastoma protein. Science 307:1114-1118.

Sakakibara S, Nakamura Y, Yoshida T, Shibata S, Koike M, Takano H, Ueda S, Uchiyama Y, Noda T, Okano H (2002) RNA-binding protein Musashi family: Roles for CNS stem cells and a subpopulation of ependymal cells revealed by targeted disruption and antisense ablation. Proc Natl Acad Sci USA 99:1519415199.

Sanai N, Tramontin AD, Quinones-Hinojosa A, Barbaro NM, Gupta N, Kunwar S, Lawton MT, McDermott MW, Parsa AT, Verdugo J M-G, Berger MS, Alvarez-Buylla A (2004) Unique astrocyte ribbon in adult humans brain contains neural stem cells but lacks chain migration. Nature 427:740-744.

Sauer F (1935) Mitosis in the neural tube. J Comp Neurol 62: 377-405.

Saunders NR, Deal A, Knott GW, Varga ZM, Nicholls JG (1995) Repair and recovery following spinal cord injury in a neonatal marsupial (monodelphus domestica). Clin Exp Pharmacol Physiol 22:518-526.

Schneider ME, Belyantseva IA, Azevedo RB, Kachar B (2002) Rapid renewal of auditory hair bundles. Nature 418:837-838.

Schulte T, Paschke KA, Laessing U, Lottspeich F, Stuermer CAO (1997) Reggie-1 and reggie-2, two cell surface proteins expressed by retinal ganglion cells during axon regeneration. Development 124:577-587.

Schwob JE (2002) Neural regeneration and the peripheral olfactory system. Anat Rec 269:33-49.

Scott TM, Foote J (1981) A study of degeneration, scar formation and regeneration after section of the optic nerve in the frog, Rana pipiens. J Anat 133:213-225.

Seaberg RM, Van der Kooy D (2002) Adult rodent neurogenic regions: the ventricular subependyma contains neural stem cells, but the dentate gyrus contains restricted progenitors. J Neurosci 22:1784-1793.

Seitz A, Aglow E, Heber-Katz E (2002) Recovery from spinal cord injury: A new transection model in the C57B1/6 mouse. J Neurosci Res 67:337-345.

Shatos MA, Mizumoto K, Mizumoto H, Kurimoto Y, Klassen H, Young MJ (2001) Multipotent stem cells from the brain and retina of green mice. J Reg Med 2:13-15 (E-biomed).

Shen Q, Goderie SK, Jin L, Karanth N, Sun Y, Abramova N, Vincent P, Pumiglia K, Temple S (2004) Endothelial cells stimulate self-renewal and expand neurogenesis of neural stem cells. Science 304:1338-1340.

Shimizu I, Oppenheim RW, Obrien M, Shneiderman A (1990) Anatomical and functional recovery following spinal cord transection in the chick embryo. J Neurobiol 21:918-937.

Shors T, Miesegaes G, Beylin A, Zhao M, Rydel T, Gould E (2001) Neurogenesis in the adult is involved in the formation of trace memories. Nature 410:372-375.

Simpson SB Jr (1965) Regeneration of the lizard tail. In: Kiortisis V, Trampusch HA (eds.). Regeneration in Animals and Related Problems. Amsterdam: North-Holland Pub Co, pp 431443.

Sinicropi DV, McIlwain DL (1983) Changes in the amounts of cyto-skeletal proteins within the perikarya and axons of regenerating frog motoneurons. J Cell Biol 96:240-247.

Smart I (1961) The subependymal layer of the mouse brain and its cell production as shown by radioautography after thymidine-H3 injection. J Comp Neurol 116:325-348.

Smith CM, Luskin MB (1998) Cell cycle length of olfactory bulb neuronal progenitors in the rostral migratory system. Dev Dynam 213:220-227.

Song H, Stevens CS, Gage FH (2002) Astroglia induce neurogenesis from adult neural stem cells. Nature 417:39-44.

Spalding KL, Bhardwaj RD, Buchholtz BA, Druid H, Frisen J (2005) Retrospective birth dating of cells in humans. Cell 122: 133-143.

Sperry RW (1944) Optic nerve regeneration with return of vision in anurans. J Neurophysiol 7:57-69.

Stensaas LJ (1983) Regeneration in the spinal cord of the newt Notophthalmus (Triturus) pyrrhogaster. In: Kao CC, Bunge RP, Reier PJ (eds.). Spinal Cord Reconstruction. New York, Raven Press, pp 121-149.

Stensaas LJ, Feringa ER (1977) Axon regeneration across the site of injury in the optic nerve of the newt Triturus pyrrhogaster. Cell Tiss Res 179:501-516.

Steward O, Schauwecker PE, Guth L, Zhang Z, Fujiki M, Inman D, Wrathall J, Kempermann G, Gage FH, Saatman KE, Raghupathi R, McIntosh T (1999) Genetic approaches to neurotrauma research: Opportunities and potential pitfalls of murine models. Exp Neurol 157:19-42.

Stocum DL (2002) A tail of transdifferentiation. Science 298: 1901-1903.

Stokes BT, Fox P, Hollinden G (1983) Extracellular calcium activity in the injured spinal cord. Exp Neurol 80:561-572.

Stone LS (1950) The role of retinal pigment cells in regenerating neural retinae of adult salamander eyes. J Exp Zool 113:9-31.

Stone JS, Cotanche DA (1994) Identification of the timing of S phase and the patterns of proliferation during hair cell regeneration in the chick cochlea. J Comp Neurol 341:50-67.

Stone JS, Rubel EW (1999) Delta 1 expression during avian hair cell regeneration. Development 126:961-973.

Stone JS, Rubel EW (2000) Avian auditory hair cell regeneration. Proc Natl Acad Sci USA 97:11714-11721.

Stone JS, Shang L, Tomarev S (2004) cProx1 immunoreactivity distinguishes progenitor cells and predicts hair cell fate during avian hair cell regeneration. Dev Dynam 230:597-614.

Stuermer CO, Bastmeyer M, Bahr M, Strobel G, Paschke K (1992) Trying to understand axonal regeneration in the CNS of fish. J Neurobiol 23:537-559.

Taylor R, Forge A (2005) Life after deaf for hair cells? Science 307:1056-1058.

Temple S (2001) The development of neural stem cells. Nature 414:112-117.

Tsonis PA, Del-Rio Tsonis K (2004) Lens and retina regeneraton: transdifferentiation, stem cells and clinical applications. Exp Eye Res 78:161-172.

Travis J (1994) Glia: The brain's other cells. Science 266:970-972.

Treherne JM, Woodward SKA, Varga ZM, Ritchie JM, Nicholls JG (1992) Restoration of conduction and growth of axons through injured spinal cord of the neonatal opossum in culture. Proc Natl Acad Sci U 89:431-434.

Tropepe V, Coles BLK, Chiasson BJ, Horsford D, Elia J, McInnes RR, van der Kooy D (2000) Retinal stem cells in the adult mammalian eye. Science 287:2032-2036.

Tsue TT, Watling DL, Weisleder P, Coltrera MD, Rubel EW (1994) Identification of hair cell progenitors and intermitotic migration of their nuclei in the normal and regenerating avian inner ear. J Neurosci 14:140-152.

Turner JT, Singer M (1974) The ultrastructure of regeneration in the severed newt optic nerve. J Exp Zool 190:249-288.

Van Praag H, Kempermann G, Gage FH (1999a) Running increases cell proliferation and and neurogenesis in the adult mouse dentate gyrus. Nature Neurosci 2:266-270.

Van Praag H, Christie BR, Sejnowski TJ, Gage FH (1999b) Running enhances neurogenesis, learning and long-term potentiation in mice. Proc Natl Acad Sci USA 96:13427-13431.

Van Praag H, Schinder AF, Christie BR, Toni N, Palmer T, Gage FH (2002) Fuctional neurogenesis in the adult hippocampus. Nature 415:1030-1034.

Wakabayashi Y, Komori H, Kawa UT, Mochida K, Takahashi M, Qi M, Otake K, Shinomiya K (2001) Functional recovery and regeneration of descending tracts in rats after spinal cord transection in infancy. Spine 26:1215-1222.

Wanner M, Lang DM, Bandtlow CE, Schwab ME, Bastmeyer M, Steuermer CA (1995) Reevaluation of the growth-permissive substrate properties of goldfish optic nerve myelin and myelin proteins. J Neurosci 15:7500-7508.

Warchol ME, Lambert PR, Goldstein BJ, Forge A, Corwin JT (1993) Regenerative proliferation in inner ear sensory epithelia from adult guinea pigs and humans. Science 259:16191622.

Wehrle B, Chiquet M (1990) Tenascin is accumulated along developing peripheral nerves and allows neurite outgrowth in vitro. Development 110:401-415.

Weiss SM, Dunne C, Hewson J, Wohl C, Wheatley M, Peterson AC, Reynolds BR (1996) Multipotent CNS stem cells are present in the adult mammalian spinal cord and ventricular neuraxis. J Neurosci 16:7599-7609.

Westerfield M (1987) Substrate interqactions affecting motor growth cone guidance during development and regeneration. J Exp Biol 132:161-176.

Willbold E, Layer PG (1992) A hidden retina regenerative capacity from the chick ciliary margin is reactivated in vitro, that is accompanied by downregulation of butyrylcholinesterase. Eur J Neurosci 4:210-220.

Yamamoto S, Nagao M, Ugimori M, Kosako H, Nakatomi H, Yamamoto N, Takebayashi H, Nabeshima Y, Kitamura T, Weinmaster G, Nakamura K, Nakafuku M (2001) Transcription factor expression and Notch-dependent regulation of of neural progenitors in the adult rat spinal cord. J Neurosci 21:98149823.

Yamashita T, Tucker KL, Barde YA (1999) Neurotrophin binding to the p75 receptor modulates Rho activity and axonal outgrowth. Neuron 24:585-593.

Yannas IV (2001) Tissue and Organ Regeneration in Adults. New York, Springer.

Yiu G, He Z (2003) Signaling mechanisms of the myelin inhibitors of axon regeneration. Curr Opin Neurobiol 13:545-551.

Zakon H, Capranica RR (1981) Reformation of organized connections in the auditory system after regeneration of the eighth nerve. Science 213:242-244.

Zamora AJ, Mutin M (1988) Vimentin and glial fibrillary acidic protein in radial glia of the adult urodele spinal cord. Neurosci 27:279-288.

Zhang FC, Clarke JDW, Ferretti P (2000) FGF-2 up-regulation and proliferation of neural progenitors in the regenerating amphibian spinal cord in vivo. Dev Biol 225:381-391.

Zhao X, Das AV, Thoreson WB, James J, Wattnem TE, Rodriguez-Sierra J, Ahmad I (2002) Adult corneal limbal epithelium: A model for studying neural potential of non-neural stem cells/ progenitors. Dev Biol 250:317-331.

Zhao X, Das A, Soto-Leon F, Ahmad I (2005) Growth factor-responsive progenitors in the postnatal mammalian retina. Dev Dynam 232:349-358.

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