Many thanks to M. Tevfik Dorak for his kind invitation to contribute to this project. Additional thanks to Russell G. Foster for his unstinting support in these studies, as well as to Jason N. Butler for his continued contribution. Data for Figure 6.2 were kindly provided by Helen Banks. Finally, thanks must also be extended to all the researchers with whom I have spoken on the subjects contained herein for providing a constant improvement of my understanding of this rapidly moving field. Support for this work was provided by the British Biotechnology and Biological Sciences Research Council, the Wellcome Trust, and Children with Leukaemia.

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