Clearance equation

- indicates the volume of plasma cleared of a substance per unit time.

- The units of clearance are ml/min and ml/24 hr.

where:

C = clearance (ml/min or ml/24 hr) U = urine concentration (mg/ml) V = urine volume/time (ml/min) P = plasma concentration (mg/ml)

- Example: If the plasma [Na+] is 140 mEq/L, the urine [Na+] is 700 mEq/L, and the urine flow rate is 1 ml/min, what is the clearance of Na+?

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