A Early proximal tubulespecial features Figure

- reabsorbs Na+ and H20 with HC03~, glucose, amino acids, phosphate, and lactate.

- Na+ is reabsorbed by cotransport with glucose, amino acids, phosphate, and lactate. These cotransport processes account for the reabsorption of all of the filtered glucose and amino acids.

- Na+ is also reabsorbed by countertransport via Na+-H+ exchange, which is linked directly to the reabsorption of filtered HC03".

- Carbonic anhydrase inhibitors (e.g., acetazolamide) are diuretics that act in the early proximal tubule by inhibiting the reabsorption of filtered HC03".

Proximal convoluted tubule

Proximal convoluted tubule

Thin ascending limb

Collecting duct

Thin descending limb

Thin ascending limb

Figure 5-7. Na* handling along the nephron. Arrows indicate reabsorption of Na*. Numbers indicate the percentage of the filtered load of Na* that is reabsorbed or excreted.

Peritubular

Lumen Cell of the early proximal tubule capillary blood

Glucose, amino acid, phosphate, lactate n3+

Figure 5-8. Mechanisms of Na+ reabsorption in the cells of the early proximal tubule.

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