AInotropic agents change the cardiac output curve

(1) Positive inotropic agents (e.g., digitalis) produce increased contractility and increased cardiac output (Figure 3-12).

- The equilibrium, or intersection, point shifts to a higher cardiac output and a correspondingly lower right atrial pressure. -Right atrial pressure decreases because more blood is ejected from the heart on each beat (increased stroke volume).

(2) Negative inotropic agents produce decreased contractility and decreased cardiac output (not illustrated).

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