Autoregulation of RBF

- is accomplished by changing renal vascular resistance. If arterial pressure changes, a proportional change occurs in renal vascular resistance to maintain a constant renal blood flow.

- RBF remains constant over the range of arterial pressures from 80 to 200 mm Hg (autoregulation).

- The mechanisms for autoregulation include:

a. Myogenic mechanism, in which the renal arterioles contract in response to stretch. Thus, increased renal arterial pressure stretches the arterioles, which contract and increase resistance to maintain constant blood flow.

b. Tubuloglomerular feedback, in which increased renal arterial pressure leads to increased delivery of fluid to the macula densa. The macula densa senses the increased load and causes constriction of the nearby afferent arteriole, increasing resistance to maintain constant blood flow.

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