B Slope of the venous return curve

- is determined by the resistance of the arterioles.

(1) A clockwise rotation of the venous return curve indicates a decrease in total peripheral resistance (TPR). When TPR is decreased for a given right atrial pressure, there is an increase in venous return (i.e., vasodilation of the arterioles "allows" more blood to flow from the arteries to the veins and back to the heart).

(2) A counterclockwise rotation of the venous return curve indicates an increase in TPR (see Figure 3-14). When TPR is increased for a given right atrial pressure, there is a decrease in venous return to the heart (i.e., vasoconstriction of the arterioles decreases blood flow from the arteries to the veins and back to the heart).

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