BNorepinephrine epinephrine and dopamine Figure 17 1 Norepinephrine

- is the primary transmitter released from postganglionic sympathetic neurons.

- is synthesized in the nerve terminal and released into the synapse to bind with a or p receptors on the postsynaptic membrane.

-is removed from the synapse by reuptake or is metabolized in the presynaptic terminal by monoamine oxidase (MAO) and catechol-O-methyltransferase (COMT). The metabolites are:

(a) 3,4-Dihydroxymandelic acid (DOMA)

(b) Normetanephrine (NMN)

(c) 3-Methoxy-4-hydroxyphenylglycol (MOPEG)

Tyrosine | tyrosine hydroxylase

L-dopa I dopa decarboxylase

Dopamine | dopamine ß-hydroxylase

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