CAcidbase

- Effectively, H+ and K+ exchange for each other across the basolateral cell membrane.

- Acidosis decreases K+ secretion. The blood contains excess H+; therefore, H* enters the cell across the basolateral membrane and K+ leaves the cell. As a result, the intracellular K+ concentration and the driving force for K+ secretion decrease.

- Alkalosis increases K+ secretion. The blood contains too little H+; therefore, H+ leaves the cell across the basolateral membrane and K+ enters the cell. As a result, the intracellular K+ concentration and the driving force for K+ secretion increase.

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