CAt a Po2 of 25 mm Hg

- hemoglobin is only 50% saturated.

- The Po2 at 50% saturation is the P50. Fifty percent saturation means that, on average, two of the four heme groups of each hemoglobin molecule have 02 bound.

Arterial blood

25 50 75

Arterial blood

25 50 75

Figure 4-6. Hemoglobin-02 dissociation curve.

3. The sigmoid shape of the curve is the result of a change in the affinity of hemoglobin as each successive 02 molecule binds to a heme site (called

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Anxiety and Depression 101

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