Causing release of neurotransmitter into the synaptic cleft

3. Neurotransmitter diffuses across the synaptic cleft and combines with receptors on the postsynaptic cell membrane, causing a change in its permeability to ions and, consequently, a change in its membrane potential.

4. Inhibitory neurotransmitters hyperpolarize the postsynaptic membrane; excitatory neurotransmitters depolarize the postsynaptic mem brane.

B. Neuromuscular junction (Table 1-2)

- is the synapse between axons of motoneurons and skeletal muscle.

- The neurotransmitter released from the presynaptic terminal is ACh, and the postsynaptic membrane contains a nicotinic receptor.

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