CCardiac glycosides digitalis

- increase the force of contraction by inhibiting Na+,K+-ATPase in the myocardial cell membrane (Figure 3-7).

- As a result of this inhibition, the intracellular [Na+] increases, diminishing the Na+ gradient across the cell membrane.

- Na+-Ca2+ exchange (a mechanism that extrudes Ca2+ from the cell) depends on the size of the Na+ gradient and is diminished, producing an increase in intracellular [Ca2+].

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