1. Pyrogens increase the production of interleukin-1 (IL-1) in phagocytic cells.
- IL-1 acts on the anterior hypothalamus to increase the production of prostaglandins. Prostaglandins increase the set-point temperature, setting in motion the heat-generating mechanisms that increase body temperature and produce fever.
2. Aspirin reduces fever by inhibiting cyclooxygenase, thereby inhibiting the production of prostaglandins. Therefore, aspirin decreases the set-point temperature. In response, mechanisms that cause heat loss (e.g., sweating, vasodilation) are activated.
3. Steroids reduce fever by blocking the release of arachidonic acid from brain phospholipids, thereby preventing the production of prostaglandins.
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Diabetes is a disease that affects the way your body uses food. Normally, your body converts sugars, starches and other foods into a form of sugar called glucose. Your body uses glucose for fuel. The cells receive the glucose through the bloodstream. They then use insulin a hormone made by the pancreas to absorb the glucose, convert it into energy, and either use it or store it for later use. Learn more...