CIncreases in arterial [H

- stimulate the carotid body peripheral chemoreceptors directly, independent of changes in Pco2.

- In metabolic acidosis, breathing rate is increased (hyperventilation) because arterial [H+] is increased and pH is decreased.

Table 4-6. Comparison of Central and Peripheral Chemoreceptors

Location

Medulla

Stimuli that Increase Breathing Rate

Central chemoreceptors l pH

Peripheral chemoreceptors

Carotid and aortic bodies

-IpH

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