Degradation of ACh

- The EPP is transient because ACh is degraded to acetyl CoA and choline by acetylcholinesterase (AChE) on the muscle end plate.

- One-half of the choline is taken back into the presynaptic ending by Na+-choline cotransport and used to synthesize new ACh.

- AChE inhibitors (neostigmine) block the degradation of ACh, prolong its action at the muscle end plate, and increase the size of the EPP.

- Hemicholinium blocks choline reuptake and depletes the presynaptic endings of ACh stores.

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