Diseasemyasthenia gravis

- is caused by the presence of antibodies to the ACh receptor.

- is characterized by skeletal muscle weakness and fatigability resulting from a reduced number of ACh receptors on the muscle end plate.

- The size of the EPP is reduced; therefore, it is more difficult to depolarize the muscle membrane to threshold to produce action potentials.

- Treatment with AChE inhibitors prolongs the action of ACh at the muscle end plate and partially compensates for the reduced number of receptors.

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