Extracellular buffers

a. The major extracellular buffer is HC03", which is produced from C02 and H20.

b. Phosphate is a minor extracellular buffer. -The pK of the H2P04VHP04 2 buffer pair is 6.8.

- Phosphate is most important as a urinary buffer; excretion of H+ as H2P04" is called titratable acid.

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