a. t oil/water partition coefficient of the solute increases solubility in the lipid of the membrane.
b. i radius (size) of the solute increases the speed of diffusion.
c. i membrane thickness decreases the diffusion distance.
- Small hydrophobic solutes have the highest permeabilities in lipid membranes.
- Hydrophilic solutes must cross cell membranes through water-filled channels, or pores. If the solute is an ion (is charged), then its flux will depend on both the concentration difference and the potential difference across the membrane.
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