Filtered load

- Increases in the filtered load of HCO:1 result in increased rates of HC03" reabsorption. However, if the plasma HCO:; concentration becomes very high (e.g., metabolic alkalosis), the filtered load will exceed the reabsorptive capacity, and HC03~ will be excreted in the urine.

- Increases in Pco2 result in increased rates of HCO:i reabsorption because the supply of intracellular H+ for secretion is increased.

- Decreases in Pco2 result in decreased rates of HC03" reabsorption because the supply of intracellular H+ for secretion is decreased.

- These effects of changes in Pco2 are the physiologic basis for the renal compensation for respiratory acidosis and alkalosis.

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