Increase K secretion

- Diuretics that increase flow rate through the distal tubule (e.g., thiazide diuretics, loop diuretics) cause dilution of the luminal K+ concentration, increasing the driving force for K+ secretion. As a result of increased K+ secretion, these diuretics cause hypokalemia.

(e) K+-sparing diuretics

- include spironolactone, triamterene, and amiloride. Spironolactone is an antagonist of aldosterone; triamterene and amiloride act directly on the principal cells.

- decrease K+ secretion. If used alone, they cause hyperkalemia.

- The most important use of the K+-sparing diuretics is in combination with thiazide or loop diuretics to offset urinary K+ losses.

(f) Luminal anions

- Excess anions in the lumen cause an increase in K+ secretion by increasing both the negativity of the lumen and the electrical driving force for K+ secretion.

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Diabetes 2

Diabetes 2

Diabetes is a disease that affects the way your body uses food. Normally, your body converts sugars, starches and other foods into a form of sugar called glucose. Your body uses glucose for fuel. The cells receive the glucose through the bloodstream. They then use insulin a hormone made by the pancreas to absorb the glucose, convert it into energy, and either use it or store it for later use. Learn more...

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