(1) The osmolarity of ECF decreases. As a result of the lack of aldosterone in adrenocortical insufficiency, the kidneys excrete more NaCl than water.
(2) ECF volume decreases. Water shifts into the cells; as a result of this shift, ICF osmolarity decreases until it equals ECF osmolarity, and ICF volume increases.
(3) Plasma protein concentration increases because of the decrease in ECF volume. Hematocrit increases because of the decreased ECF volume and because the RBCs swell as a result of water entry.
(4) Arterial blood pressure decreases because of the decrease in ECF volume.
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