Is called the diluting segment

- reabsorbs NaCl by the Na+-K+-2C1~ cotransporter.

Drink water

1

Decreases plasma osmolarity

i

Inhibits osmoreceptors in anterior hypothalamus

Inhibits osmoreceptors in anterior hypothalamus

Decreases secretion of ADH from posterior pituitary

Decreases water permeability of late distal tubule and collecting duct

Decreases urine osmolarity and increases urine volume

Decreases urine osmolarity and increases urine volume

i

r

Increases plasma osmolarity toward normal

Figure 5-14. Responses to water intake. ADH = antidiuretic hormone.

Figure 5-14. Responses to water intake. ADH = antidiuretic hormone.

- is impermeable to H20. Therefore, H20 is not reabsorbed with NaCl and the tubular fluid becomes dilute.

- The fluid that leaves the thick ascending limb has an osmolarity of 100 mOsm/L and TF/Posin < 1.0 as a result of the dilution process.

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