protects the brain from endogenous or exogenous toxins.
2. It prevents the escape of neurotransmitters from their functional sites in the CNS into the general circulation.
3. Drugs penetrate the blood-brain barrier to varying degrees. For example, nonionized (lipid-soluble) drugs cross more readily than ionized (water-soluble) drugs.
- Inflammation, irradiation, and tumors may destroy the blood-brain barrier and permit entry into the brain of substances that are usually excluded (e.g., antibiotics, radiolabeled markers).
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