Sample calculation for diffusion

- The urea concentration of blood is 10 mg/100 ml. The urea concentration of proximal tubular fluid is 20 mg/100 ml. If the permeability to urea is 1 x 10-5 cm/sec and the surface area is 100 cm2, what are the magnitude and direction of the urea flux?

sec

1 x

10"5

cm'

sec

1 x

10"6

= 1 x 10~4 mg/sec from lumen to blood (high to low concentration)

- Note: The minus sign preceding the diffusion equation indicates that the direction of flux, or flow, is from high to low concentration. It can be ignored if the higher concentration is called Ci and the lower concentration is called C2.

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