Steps in the reninangiotensinaldosterone system

a. A decrease in renal perfusion pressure causes the juxtaglomerular cells of the afferent arteriole to secrete renin.

b. Renin catalyzes the conversion of angiotensinogen to angiotensin I in plasma.

c. Angiotensin-converting enzyme (ACE) catalyzes the conversion of angiotensin I to angiotensin II, primarily in the lungs.

- ACE inhibitors (e.g., captopril) block the conversion of angiotensin I to angiotensin II and, therefore, decrease blood pressure.

d. Angiotensin II has two effects:

(1) It stimulates the synthesis and secretion of aldosterone by the adrenal cortex.

- Aldosterone increases sodium chloride (NaCl) reabsorption by the renal distal tubule, thereby increasing blood volume and arterial pressure.

- This action of aldosterone is slow because it requires new protein synthesis.

Was this article helpful?

0 0
Anxiety and Depression 101

Anxiety and Depression 101

Everything you ever wanted to know about. We have been discussing depression and anxiety and how different information that is out on the market only seems to target one particular cure for these two common conditions that seem to walk hand in hand.

Get My Free Ebook

Post a comment