Some authors recommend that a benign FNAB should be confirmed by a second FNAB 6-12 months later, because of a false-negative rate of up to 6% of the initial FNAB . The decision to subject patients to a second FNA has to be balanced against the probability of nondiagnostic aspirate,false-positive results (e.g. Thy3 in up to 7% of cases) necessitating surgery, reduction in cost-effectiveness, and heightened patient anxiety . A small proportion of patients will develop new nodules or enlargement of their existing nodule, and some will develop thyroid dysfunction; therefore some form of follow-up seems appropriate, although the optimal means of achieving this is unknown.
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