The prognosis in patients with residual/ metastatic MTC is overall poorer than that of patients with WDTC [101,113]. There is an early tendency for MTC to metastasize to the lungs and bone. Treatment of patients with persistent MTC remains controversial. Van Heerden et al.  reported a study of 31 patients with MTC who had 5- and 10-year survival rates of 90% and 86%, respectively. It is hoped that vigorous screening of MEN2A/B and FMTC family members will lead to early surgical intervention with T/NTT and rigorous life-long follow-up in RET mutation-carrying pedigree members,thus leading to increased survival for patients with these tumors [102,115].
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