Catharanthus Roseus As A Source Of Terpenoid Indole Alkaloid Production

Catharanthus roseus plant cell cultures are a potential commercial source for the production of some pharmaceutically important alkaloids. Catharanthus roseus (L.) G. Don is a tropical plant belonging to the family Apo-cynaceae and produces a wide range of terpenoid indole alkaloids (TIAs). More than 130 alkaloids have been isolated from different parts of the plant and many of them show biological activities, such as the antineoplastic vinblastine and vincristine, the antihypertensive ajmalicine, and the sedative serpentine (23-25). Cell suspension cultures of C. roseus do not represent an exception for secondary metabolite production regarding the obstacles mentioned before. They produce a much simpler alkaloid profile, the yield is less than that from intact plants (26-29), and after prolonged subculture they lose the ability to produce alkaloids at high levels even after extensive

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