Hepatitis A Vaccine

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Several inactivated and attenuated hepatitis A vaccines have been developed and evaluated in human clinical trials and in nonhuman primate models of hepatitis A virus infection (D'Hondt, 1992); however, only inactivated vaccines have been evaluated for efficacy in controlled clinical trials (Innis et al., 1994). The vaccines licensed currently are Havrix (SmithKline Beecham Bio-logicals), Vaqta (Merck and Co., Inc.), Avaxim (Pasteur Merieux Connaught) and Epaxal (Berna Products). All four are inactivated vaccines.

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