The hepatitis B vaccine may be administered during pregnancy. Hepatitis B virus infection is a risk for short-term and long-term travelers who may be exposed to blood or body fluids. The risk is increased for travel to Asia, sub-Saharan Africa, the Amazon basin and parts of the Middle East. The main risk factors for a pregnant woman include working in a health care setting, being sexually active with a new partner, planning delivery overseas, or planning extended travel.
Ideally, all pregnant women should be screened for hepatitis B carriage. If a woman is positive for hepatitis B surface antigen (HBsAg) her infant should be given hepatitis immune globulin and hepatitis B vaccine at birth. The hepatitis B vaccine can be administered to pregnant women. It is preferred that it is given after the first trimester (for theoretical reasons) to all women who are at high risk and test negative by serology for past infection.
Immunization for hepatitis B will also prevent hepatitis D infection.
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