Chromosomal Abnormalities in Molar Pregnancy

Partial and complete hydatidiform moles occur with a frequency of approximately 1 in 1500 pregnancies in the United States; they are more common (1 in 250 pregnancies) in Asia. These moles have a risk of becoming invasive tumors.

A complete hydatidiform mole (CHM) consists of hyperplastic trophoblastic tissue without evidence of fetal development. The chromosomes in a CHM are of paternal origin. This entity can arise by fertilization of an enucleate (empty) ovum in one of two scenarios. The ovum may be fertilized with a single sperm, the chromosomes then undergoing duplication to form a diploid cell that forms trophoblastic tissue. In this scenario, the sperm must carry the X chromosome in order for the resulting cell to be viable. Alternatively, an enucleate ovum is fertilized by two sperm (X/X or X/Y), giving rise to a diploid cell that forms trophoblastic tissues.

A partial hydatidiform mole (PHM) is produced when two sperm fertilize a normal ovum. PHMs can also arise from fertilization of an ovum by a single sperm that subsequently undergoes chromosomal duplication. In either case, the resulting cell is triploid (i.e., the kary-otype is 69, XXX or 69, XYY). In this situation, both trophoblastic and fetal tissues can develop, and very rarely a fetus with triploidy can survive to term, although the postnatal life expectancy is extremely short. Approximately 16% of spontaneous abortions show triploidy.

Was this article helpful?

0 0
The Latest Anti Aging Treatments

The Latest Anti Aging Treatments

Are You Striving To Look And Feel Youthful? Wish You Could Add 20 Years To Your Life? Discover the Secrets to a Longer, Healthier Life With This Fantastic Anti-Aging Resource. You might be feeling and looking great now, but have you ever thought about what youll feel and look like several years from now? Have you ever considered that the choices you make today directly influence how well you age?

Get My Free Ebook


Post a comment