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The rotarod is an established test for evaluating pharmacological actions of psychotropic agents such as skeletal muscle relaxants, anticonvulsants, and antidepressants in the central or peripheral nervous system (Dunhan and Miya, 1957). Morimoto and Kito (1994) have shown that this test is useful to evaluate the antidepressive effects of serotonergic and adrenergic antidepressants. As shown in Figure 5, chronic stress impaired the rotarod performance, concomitant with unchanged traction performance and locomotor activity, suggesting that the impaired rotarod performance is not due to muscle relaxation or motor dysfunction. As antidepressants increase the riding time on the rotating rod in normal rats (Morimoto and Kito, 1994), the impaired rotarod performance suggests a depressive behavioral state.

Figure 5: Time course of changes in behavioral performance during a 4-week stress session and a 10-day recovery period. A, rotarod performance; B, traction performance; C, locomotor activity. In the rotarod test, the riding time was not affected at day 1 or week 1. However, the riding time was significantly decreased at week 4 and the recovery. In the traction test, the clinging time did not change during the stress and recovery periods. In the locomotor test, the activity was significantly decreased at week 1, but was not affected at day 1, week 4, or the recovery. Each column is the mean ± S.E.M. of 10 or 16 rats per group. Asterisks indicate a significant difference from naive nonstressed rats in each time point, *p < 0.05, ***p < 0.001. D, day; W, week. Data are derived from Mizoguchi et al. (2002a) with permission.

Figure 5: Time course of changes in behavioral performance during a 4-week stress session and a 10-day recovery period. A, rotarod performance; B, traction performance; C, locomotor activity. In the rotarod test, the riding time was not affected at day 1 or week 1. However, the riding time was significantly decreased at week 4 and the recovery. In the traction test, the clinging time did not change during the stress and recovery periods. In the locomotor test, the activity was significantly decreased at week 1, but was not affected at day 1, week 4, or the recovery. Each column is the mean ± S.E.M. of 10 or 16 rats per group. Asterisks indicate a significant difference from naive nonstressed rats in each time point, *p < 0.05, ***p < 0.001. D, day; W, week. Data are derived from Mizoguchi et al. (2002a) with permission.

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Defeat Depression

Defeat Depression

Learning About How To Defeat Depression Can Have Amazing Benefits For Your Life And Success! Discover ways to cope with depression and melancholic tendencies! Depression and anxiety particularly have become so prevalent that it’s exceedingly common for individuals to be taking medication for one or even both of these mood disorders.

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